Computation Analysis of Indian Genes
✓Recently, the results from the computation analysis of the 1029 sequenced genomes from India were published in the scientific journal, Nucleic Acid Research.
✓The analysis was carried out by CSIR constituent labs, Institute of Genomics and Integrative Biology (IGIB), Delhi and Centre for Cellular and Molecular Biology (CCMB), Hyderabad.
✓The analysis has found that out of approximately 55.8 million single nucleotide variants in India, around 18.01 million (32.23%) variants are unique and found only in the samples sequenced from India.
✓Thus, India-centric population genomic initiative becomes important.
✓A genome is all the genetic matter in an organism.
✓It is defined as an organism’s complete set of DNA including all of its genes.
✓Every organism’s genetic code is contained in its DNA, the building blocks of life.
✓Each genome contains all of the information needed to build and maintain that organism.
✓In humans, a copy of the entire genome contains more than 3 billion DNA base pairs.
✓Genome sequencing means figuring out the order of Adenine, Cytosine, Guanines, and Thymine (DNA nucleotides) in a genome
✓Application: (1) Crucial role for new advancements in medical science; (2) In disease management; (3) Researchers and clinicians can easily detect the disease related to genetic disorder.
✓The study of entire genome sequences will help understand how genes work together to direct the growth, development and maintenance of an entire organism.
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